Renal Physiology

Regulation of Body Fluid Compartments: Extracellular and Intracellular Fluids; Edema

Guyton & Hall Text Book of Medical Physiology Ch 25, Ed 15

Regulation of Body Fluid Compartments

Extracellular Edema

The Urinary System: Functional Anatomy and Urine Formation by the Kidneys

Guyton & Hall Text Book of Medical Physiology Ch 26, Ed 15

Introduction to Renal Physiology

Learning objectives:

1.Describe the physiological anatomy of kidney

2.Describe in sequence the tubular segments through which ultrafiltrate flows

3.Distinguish between cortical and juxtamedullary nephrons

4.Enlist the homeostatic functions of kidneys

5.Distinguish between filtration, reabsorption, and secretion at the level of a nephron

Physiological Anatomy of Kidney & Mechanism of Urine Formation

Micturition & its Abnormalities

Glomerular Filtration, Renal Blood Flow, and Their Control

Guyton & Hall Text Book of Medical Physiology Ch 27, Ed 15

GFR, Renal Blood Flow & Filtration Fraction

Determinants and Regulation of GFR & Renal Blood Flow

Learning Objectives:

1.Explain the physiological control of glomerular filtration and renal blood flow

2.Describe the autoregulatory mechanismsvthat mediate the regulation of renal plasma flow and glomerular filtration rate

Renal Tubular Reabsorption and Secretion

Guyton & Hall Text Book of Medical Physiology Ch 28, Ed 15

Basics of Renal Tubular Processing

Renal Tubular Processing across PCT and Loop of Henle

Renal Tubular Processing across DCT and Collecting Tubule

Regulation of Renal Tubular Processing

Renal Clearance

Urine Concentration and Dilution; Regulation of Extracellular Fluid Osmolarity and Sodium Concentration

Guyton & Hall Text Book of Medical Physiology Ch 29, Ed 15

Mechanism of Dilute Urine Formation

Mechanism of Concentrated Urine Formation & Related Disorders

Mechanism of Concentrated Urine Formation

Learning Objectives:

Explain the mechanism of concentrated urine formation
Enumerate requirements for excreting a concentrated urine— high ADH levels and hyperosmotic renal medulla
Discuss the countercurrent mechanism for generating a hyperosmotic renal medullary interstitium
Explain the role of distal tubule and collecting duct in concentrated urine formation
Discuss the role of urea for generating hyperosmotic renal medullary interstitium and in the formation of concentrated urine
Describe the countercurrent exchange in the vasa recta in preservation of hyperosmolarity of the renal medulla

Regulation of Serum Osmolarity and Sodium Concentration

Learning Objecives:

Discuss free water clearance
Differentiate between diabetes insipidus and SIADH
Describe the control of extracellular fluid osmolarity and sodium concentration in terms of the osmoreceptor-ADH system and thirst mechanism
Describe the roles of Angiotensin II, Aldosterone, and salt appetite mechanism in the control of extracellular fluid osmolarity and sodium concentration

Renal Regulation of Potassium, Calcium, Phosphate, and Magnesium; Integration of Renal Mechanisms for

Control of Blood Volume and Extracellular Fluid Volume

Guyton & Hall Text Book of Medical Physiology Ch 30, Ed 15

Through this lecture, you will be able to

Describe renal tubular regulation of potassium, calcium, phosphate and magnesium.
Crtically analyze the factors imapcting renal regulation of electrolytes.